Vitamin C: A Potential Life-saving Treatment For Sepsis and Burns

This short article about IV vitamin C originally appeared in Medical News Today, www.medicalnewstoday.com on November 19, 2010. Since the FDA is taking action against manufacturers of IV vitamin C (IVC) by declaring it a new unapproved drug, it is timely to see a university research institute supporting rational use of IVC to treat serious  illness that may not respond to drugs.

Physicians caring for patients with sepsis may soon have a new safe and cost-effective treatment for this life-threatening illness. Research led by Dr. Karel Tyml and his colleagues at The University of Western Ontario and Lawson Health Research Institute have found that vitamin C can not only prevent the onset of sepsis, but can reverse the disease.

Sepsis is caused by a bacterial infection that can begin anywhere in your body. Your immune system goes into overdrive, overwhelming normal processes in your blood. The result is that small blood clots form, blocking blood flow to vital organs. This can lead to organ failure. Babies, the elderly and those with weakened immune systems are most likely to get sepsis. But even healthy people can become deathly ill from the disease.

According to Dr. Tyml, a professor at Western’s Schulich School of Medicine & Dentistry, patients with severe sepsis have a high mortality rate, nearly 40 percent, because there is no effective treatment.

“There are many facets to sepsis, but the one we have focused on for the past 10 years is the plugging of capillaries,” says Dr. Tyml. Plugged capillaries prevent oxygenation and the supply of life-supporting materials to your organ tissue and stop the removal of metabolic waste product. Plugged capillaries are seen in organs of septic patients. These organs may eventually fail, leading to multiple organ failure and death. Dr. Tyml’s lab was the first to discover this plugging by using intravital microscopy, a technique Dr. Tyml pioneered in Canada.

According to Dr. Tyml’s most recent publication, oxidative stress and the activated blood clotting pathway are the major factors responsible for the capillary plugging in sepsis. Through his research, Dr. Tyml has discovered that a single bolus of vitamin C injected early at the time of induction of sepsis, prevents capillary plugging. He has also found that a delayed bolus injection of vitamin C can reverse plugging by restoring blood flow in previously plugged capillaries.

“Our research in mice with sepsis has found that early as well as delayed injections of vitamin C improves chance of survival significantly,” explains Dr. Tyml. “Furthermore, the beneficial effect of a single bolus injection of vitamin C is long lasting and prevents capillary plugging for up to 24 hours post-injection.”

Dr. Tyml and his colleagues are eager to find appropriate support to move this research from the bench to the bedside to see if these findings translate to patients with sepsis.

The potential benefit of this treatment is substantial. “Vitamin C is cheap and safe. Previous studies have shown that it can be injected intravenously into patients with no side effects,” says Dr. Tyml. “It has the potential to significantly improve the outcome of sepsis patients world-wide. This could be especially beneficially in developing countries where sepsis is more common and expensive treatments are not affordable.”

Source:
Kathy Wallis
University of Western Ontario

IVC is also showing promise as a treatment for burns. Here is a short excerpt from http://emedicine.medscape.com/article/1277360-overview.

Vitamin C1, 2

A great deal of interest exists in using antioxidants as adjuncts to resuscitation to try to minimize oxidant-mediated contributions to the inflammatory cascade. In particular, megadose vitamin C infusion during resuscitation has been studied at some length. Some animal models have demonstrated that infusion of vitamin C within 6 hours postburn can lower calculated resuscitation values by up to one half. Whether this phenomenon can be reproduced successfully in human subjects has not been clearly demonstrated.

Proponents have reached no consensus regarding the proper total dose. Some have adopted the strategy of placing up to 10 g in a liter of RL solution, infusing it at 100 mL/h (1 g/h vitamin C), and counting the volume as part of the resuscitation volume. Recently published data using an infusion of 66 mg/kg/h during the first 24 hours demonstrate a 45% decrease in the required fluid resuscitation in a small group of patients.

The safety of high-dose vitamin C has been established in humans, at least for the short-term, but this strategy is probably less safe in patients who are pregnant, those with renal failure, and those with a history of oxalate kidney stones.

  1. Sakurai M, Tanaka H, Matsuda T, et al. Reduced resuscitation fluid volume for second-degree experimental burns with delayed initiation of vitamin C therapy (beginning 6 h after injury). J Surg Res. Nov 1997;73(1):24-7. [Medline].
  2. Tanaka H, Matsuda T, Miyagantani Y, et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg. Mar 2000;135(3):326-31. [Medline].

Please note that both references are from Japan; perhaps there is less peer pressure to avoid non-pharmaceutical treatments in Japan, even though these treatments are safe and effective. Here is a 1992 article from the same group.

Burns. 1992 Apr;18(2):127-31.
High-dose vitamin C therapy fro extensive deep dermal burns.
Matsuda T
, Tanaka H, Shimazaki S, Matsuda H, Abcarian H, Reyes H, Hanumadass M.

Abstract

We studied the haemodynamic effects of antioxidant therapy with high-dose vitamin C administration (170 mg/kg/24 h) in guinea-pigs with 70 per cent body surface area deep dermal burns. The animals were divided into three groups of six animals each. Group 1 was resuscitated with Ringer’s lactate solution according to the Parkland formula; group 2 with 25 per cent of the Parkland formula with vitamin C; and group 3 with 25 per cent of the Parkland formula without vitamin C. There were no significant differences in heart rates or in blood pressures between the groups throughout the 24-h study period. Group 3 showed significantly higher haematocrit values at 3 h postburn and thereafter as compared with those of group 2. The cardiac output values of group 2 were significantly higher than those of group 3, but equivalent to those of group 1. The water content of the burned skin in group 2 was significantly lower than that in the other groups, indicating that increased postburn capillary permeability was minimized by the administration of vitamin C. With adjuvant high-dose vitamin C administration, we were able to reduce the 24-h resuscitation fluid volume from 4 ml/kg/per cent burn to 1 ml/kg/per cent burn, while maintaining adequate cardiac output.

Here are two bullet points from an article from the Journal of Burn Care & Research July/August 2007. Burn Resuscitation by David G. Greenhalgh,

A multicenter trial to examine the role of vitamin C during burn shock resuscitation should be performed.

The last topic for investigation is to test an agent that will reduce the capillary leak that occurs during burn shock. The investigation of high dose vitamin C seems to make the most sense for the first trial.




Scroll to Top
  • $0.00
Vertisis Custom Pharmacy

Vertisis Custom Pharmacy

Vertisis is one of the most unique sterile-injectable compounding pharmacies in the United States. Our focus is on going “above and beyond” traditional compounding pharmacies by raising the standards of 503A compounding pharmacies to include exceptional products, unique delivery, advanced education, and an amazing relationship with health care providers with a seamless delivery of care. Vertisis originates from over 20 years of clinical practice in custom compounded pharmaceutical agents and over 100 years of combined compounding pharmacy experience with clinical usage of the latest technologies. We have intimate knowledge of hundreds of thousands of custom compounded pharmaceutical treatments with a team of knowledgeable pharmacists to help answer your questions.

Sign up to receive seminar news and updates!

TransLite LLC

345 Commerce Green Blvd.
Sugar Land, TX 77478

TransLite LLC is a small high tech company comprising dedicated people who design, manufacture and sell medical devices that can help reduce the pain and trauma to patients during venous access and treatment of varicose veins.
Our mission is
• To design innovative medical products that help mankind
• Produce highest quality products at affordable prices
• Provide excellent service and support to our customers
We are accomplishing our mission by providing Veinlites® to healthcare professionals all over the world. Since 1999, over 40,000 medical professionals have come to rely on Veinlite® vein finders for simple and consistent one-stick vein access. If failed IV attempts are a daily occurrence among your team, don’t get frustrated…get Veinlite®!

Phone: (281) 240-3111
Fax: (281) 240-3122

With Veinlite® products, you can locate and access veins within seconds – even in the most difficult patients whether due to their age, weight, or skin tone.
Please visit www.veinlite.com or contact us for more information at info@veinlite.com or 281-240-3111.

McGuff Family of Companies

Legacy Corporate Contributor
2921 W. MacArthur Blvd., Suite 142
Santa Ana, CA 92704

McGuff Company Inc. is a wholesale distributor of over 5,000 competitively prices pharmaceuticals, IV related products, physician office & exam room supplies and an extensive oral nutritional line to support your patient’s treatments. Our experienced customer service staff are experts at finding hard-to-find products. We maintain close relations with both large and small manufacturers of quality products to assure we will meet all of your needs. Competitive prices for over 35 years!

Verified-Accredited Wholesale Distributor (VAWD)
Phone (800) 854-7220 Toll Free
Fax (714) 540-5614 Toll Free Fax

McGuff Compounding Pharmacy Services specialty pharmacy compounding all dosage forms – preservative-free injections, amino acids, natural hormones and custom formulations all at competitive prices. Injectables are tested for particulates, sterility and endotoxins.

Accredited by the Pharmacy Compounding Accreditation Board (PCAB) &
Independently certified as ISO 9001-2008
Phone (877) 444-1133 Toll Free
Fax (877) 444-1155 Toll Free Fax

SterileDrugs.com

P.O. Box 308
Ada, MI 49301-0308
Toll-Free: (844) 733-7847
info@steriledrugs.com

SterileDrugs.com is committed to helping medical providers and practices overcome the challenges of acquiring the very best custom and non-custom medications. By contracting with multiple FDA-Registered Outsourcing Facilities (503B pharmacies), our goal is to be your source, resource, and solution for the highest quality medications at the most competitive prices.

About SterileDrugs.com
SterileDrugs.com partners with 503B pharmacies that specialize in manufacturing medications for IV Nutritional Therapy, Hormone Replacement Therapy & Weight Loss. Our pharmacy partners are held to the highest quality standards by the FDA and comply with USP 795, 797 & cGMP guidelines. For a complete list of the medications we offer, as well as pricing, please contact us at: www.steriledrugs.com or 844-73DRUGS

Doctor’s Data, Inc.

3755 lllinois Avenue.
St. Charles, IL 60174 – 2420 USA
US and Canada (800) 323-2784

Doctor’s Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced, CLIA-licensed clinical laboratory since 1972. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, hormone and HPA/adrenal function status, cardiovascular risk, liver and metabolic abnormalities, and more.

Simply O3

We help you get started with ozone therapy in your clinic – Grow your income and improve patient outcomes.  Download the DEFINITIVE Guide to Getting Started with Ozone Therapy by going to www.DrsOzone.com/Guide.  Full training and support available  Equipment has a 6 month money back guarantee and is easy to use.  Go download your FREE guide to getting started now at www.drsozone.com/guide.

Merit Pharmaceutical

2611 N. San Fernando Road
Los Angeles, CA 90065
Phone (800) 421-9657 Toll Free US & Canada
Fax (323) 227-4833
solutions@meritpharm.com

Offering IV infusion from Merit? Getting your med/surg/pharma from us? Your colleagues are and they have higher profits. Merit supplies Anti Aging/Aesthetic/Integrative practitioners better prices on the products you use. Call us and learn why successful clinics partner with Merit. IV Therapy Nutrition/Hydration, Weight Loss, Hormones, IV solutions, PRP products, exam/surgical supplies and more. Merit offers pharmaceuticals (2, 3, 3N, 4), and related medical products. www.meritpharm.com or (800) 69-MERIT

Perfect Balance

Perfect Balance, Inc. is providing new hope for cancer victims. We have a proprietary formula which destroys the enzymatic protection of cancer cells and greatly increases NK cell activity. By inhibiting the production of Nagalase the cancer cell can no longer stop the immune system  from doing its job. Innate GC Maf resumes and rapid tumor breakdown is evident. Salicinium enhances NK cell activity and has been shown to kill
both Circulating Tumor Cells and Cancer Stem Cells.

Perfect Balance, Inc. has been in business for more than 25 years and has spent most of that time working in the field of cancer

AMARC Enterprises / POLY-MVA

Contributor, Sponsor and Supporter
San Diego, CA 92021
Phone (866) 765-9682 Toll Free or (619) 447-6500
Fax (619) 447-6501
solutions@meritpharm.com

AMARC Enterprises and Poly-MVA endeavor to treat people honestly and with integrity, and to promote healthy living through our search for the highest quality products. We seek to improve the health and quality of life through practitioners and patients in integrative and regenerative medicine. We know that through smart and targeted therapies with efficacious products people can live fuller, longer and happier lives. Since 2001, AMARC and PolyMVA have been providing quality, FDA compliant products that have helped thousands of people achieve better health.

Lipoic Acid Mineral Complex is the key component that makes Poly-MVA a uniquely-formulated supplement, containing a proprietary blend of the mineral palladium bonded to alpha-lipoic acid, Vitamins B1, B2 and B12, formyl-methionine, N-acetyl cysteine, plus trace amounts of molybdenum, rhodium, and ruthenium. Poly-MVA assists in boosting immune response by targeting key pathways with very specific nutrients and supports cellular metabolism. What makes Poly-MVA unique is the proprietary manufacturing process by which the mineral palladium is sequestered to lipoic acid and thiamin. No other company produces a product similar to Poly-MVA because of the preparation and bonding process through which LAMC is manufactured. The proprietary formulation of LAMC with other vitamins, minerals, and amino acids provides considerable targeted protection and mitochondrial support, helping to enable optimum functioning of multiple essential body systems.

Send in a test question for extra credit. We may add it to future exams!

Sorry. You must be logged in to view this form.